Mycobacterium tuberculosis immunization
AssigneePowderJect Vaccines, Inc.
InventorsMichael D. Macklin, Deborah L. Fuller
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Abstract
Recombinant nucleic acid molecules are described. The molecules have a sequence or sequences encoding at least two M. tuberculosis antigens. Vectors and compositions containing these molecules are also described. In addition, compositions containing a cocktail of recombinant nucleic acid molecules having a sequence or sequences encoding one or more M. tuberculosis antigens are described. Methods of eliciting an immune response using these molecules and compositions are also described.
Claims33
A method for eliciting an immune response against M. tuberculosis in a human subject, said method comprising:
- (a) obtaining a vector construct, wherein the vector construct comprises a recombinant polynucleotide comprising a plurality of sequences each encoding a Mycobacterium tuberculosis antigen and each operably linked to control sequences suitable for expression in the subject;
- and
- (b) administering said vector construct to the human subject whereby said antigens are expressed in the human subject at sufficient levels to elicit an immune response.
A method for eliciting an immune response against M. tuberculosis in a human subject, said method comprising:
- (a) obtaining a composition containing a plurality of recombinant polynucleotides each comprising a sequence encoding a Mycobacterium tuberculosis antigen operably linked to control sequences suitable for expression in the subject;
- and
- (b) administering the composition to the human subject whereby each said antigen is expressed in the human subject at sufficient levels to elicit an immune response.
A method for eliciting an immune response to M. tuberculosis in a human subject, said method comprising:
- (a) providing a core carrier with a vector construct, wherein the vector construct comprises a recombinant polynucleotide comprising a plurality of sequences each encoding a Mycobacterium tuberculosis antigen and each operably linked to control sequences suitable for expression in the subject;
- and
- (b) administering the coated core carrier to the human subject using a particle-mediated delivery technique, wherein the M. tuberculosis antigens are expressed in the human subject at sufficient levels to elicit an immune response.
A method for eliciting an immune response to M. tuberculosis in a human subject, said method comprising:
- (a) providing a core carrier coated with a composition containing a plurality of recombinant polynucleotides each comprising a sequence encoding a Mycobacterium tuberculosis antigen operably linked to control sequences suitable for expression in the subject;
- and
- (b) administering the coated core carrier to the human subject using a particle-mediated delivery technique, wherein the M. tuberculosis antigens are expressed in the human subject at sufficient levels to elicit an immune response.
Dependencies are inferred from the claim text.