Administration of a thiol-based chemoprotectant compound
AssigneesOregon Health & Science University, The United States of America as represented by the Department of Veterans Affairs
InventorsEdward A. Neuwelt, Leslie Muldoon, Michael A. Pagel
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Abstract
A method of administration of a thiol-based chemoprotectant agent including NAC (N-acetylcysteine) and STS (sodium thiosulfate) that markedly affects biodistribution and protects against injury from diagnostic or therapeutic intra-arterial procedures. A method for treating or mitigating the side effects of cytotoxic cancer therapy for tumors located in the head or neck and brain tumors. The thiol-based chemoprotectant agent is administered intra-arterially with rapid and first pass uptake in organs and tissues other than the liver.
Claims2
A method for treating or mitigating myelosuppression, comprising:
- administering intravenously a high-dose thiol based chemoprotectant agent wherein the high-thiol based chemoprotectant agent is N-acetylcysteine(NAC).
Dependencies are inferred from the claim text.