Delivery of antiemetics through an inhalation route

A method of producing a drug selected from the group consisting of dolasetron, granisetron and metoclopramide in an aerosol form comprising:

• a. heating a thin layer containing the drug, on a solid support, to produce a vapor of the drug, and
• b. providing an air flow through the vapor to form a condensation aerosol characterized by less than 10% drug degradation products by weight, and an MMAD of less than 5 microns.

A condensation aerosol for delivery of dolasetron, wherein the condensation aerosol is formed by heating a thin layer containing dolasetron, on a solid support, to produce a vapor of dolasetron, and condensing the vapor to form a condensation aerosol characterized by less than 5% dolasetron degradation products by weight, and an MMAD of about 0.2 to 3 microns.

A condensation aerosol for delivery of granisetron, wherein the condensation aerosol is formed by heating a thin layer containing granisetron, on a solid support, to produce a vapor of granisetron, and condensing the vapor to form a condensation aerosol characterized by less than 5% granisetron degradation products by weight, and an MMAD of about 0.2 to 3 microns.

A condensation aerosol for delivery of metoclopramide, wherein the condensation aerosol is formed by heating a thin layer containing metoclopramide, on a solid support, to produce a vapor of metoclopramide, and condensing the vapor to form a condensation aerosol characterized by less than 5% metoclopramide degradation products by weight, and an MMAD of about 0.2 to 3 microns.

A method of producing dolasetron in an aerosol form comprising:

• a. heating a thin layer containing dolasetron, on a solid support, to produce a vapor of dolasetron, and
• b. providing an air flow through the vapor to form a condensation aerosol characterized by less than 5% dolasetron degradation products by weight, and an MMAD of about 0.2 to 3 microns.

A method of producing granisetron in an aerosol form comprising:

• a. heating a thin layer containing granisetron, on a solid support, to produce a vapor of granisetron, and
• b. providing an air flow through the vapor to form a condensation aerosol characterized by less than 5% granisetron degradation products by weight, and an MMAD of about 0.2 to 3 microns.

A method of producing metoclopramide in an aerosol form comprising:

• a. heating a thin layer containing metoclopramide, on a solid support, to produce a vapor of metoclopramide, and
• b. providing an air flow through the vapor to form a condensation aerosol characterized by less than 5% metoclopramide degradation products by weight, and an MMAD of about 0.2 to 3 microns.