US 7,019,033 B2 · 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives

Abstract

Phenylamino benzoic acid, benzamides, and benzyl alcohol derivatives of the formula where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, and Z is COOR7, tetrazolyl, CONR6R7, or CH2OR7, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as inflammation, psoriasis and restenosis, as well as stroke, heart failure, and immunodeficiency disorders.

Claims11

Dependent claims

A compound of the formula:

wherein:
R1 is halo or CH3;
and
R3, R4 and R5 are independently halo or hydrogen;
or a pharmeceutically acceptable salt from thereof.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

10/315,654Filed 10 Dec 2002 · division

Priority

1 Jul 1997

Published

US 2003/0149015 A17 Aug 2003

Granted

28 Mar 2006

Term ends

Not estimatedThe source records don’t support an estimate.

Classification23 codes

C07D 213/40
Radicals substituted by singly-bound nitrogen atoms: acylated substituent nitrogen atom
C07C 215/68
Compounds containing amino and hydroxy groups bound to the same carbon skeleton: having amino groups bound to carbon atoms of six-membered…
C07C 229/58
With amino and carboxyl groups bound in ortho-position: having the nitrogen atom of at least one of the amino groups further bound to a carbon…
C07C 237/08
The carbon skeleton being acyclic and saturated: having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon…

Family

Application60/051,433Us provisional application · filed 1 Jul 1997

PCT/US98/13105Parent of this division · filed 24 Jun 1998

Application09/931,596Parent of this division · filed 16 Aug 2001

US 2003/0149015 A1Pre-grant publication · published 7 Aug 2003

US 6,492,363 B2Parent of this division

Application09/462,319Parent of this division

US 6,310,060 B1Parent of this division

US 2002/0022647 A1Published application

US 7,019,033 B2This patent

From the US filing history. Foreign family members aren’t listed.

2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives

Life of this patent

2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives

Life of this patent

Abstract

Claims11