Skin whiteners containing hydroxytetronic acid derivatives
OwnerNicholas V. Perriconeinventor
Life of this patent
Estimating the term…
Abstract
Skin whitening compositions contain at least one α-hydroxytetronic derivative such as diphenyl hydroxytetronic acid. Some embodiments contain adjunct ingredients that enhance the efficacy and stability of skin whitening formulations such as a tetronic acid derivative that inhibits tyrosinase or tyrosine phosphatase, hydroquinone, an α-hydroxy acid such as glycolic acid, and a fatty acid ester of ascorbic acid such as ascorbyl palmitate.
Claims20
A method for whitening skin comprising topically administering to the skin an effective amount of a composition containing from about 0.5% to about 25% by weight of a hydroxytetronic acid derivative active ingredient having the formula
- where R1 has the formula —(CH2)n-φ, where φ is a substituted or unsubstituted phenyl group and n=0 to 6 and R2 is hydrogen, a substituted or unsubstituted alkyl group, a substituted or unsubstituted cycloalkyl group, a substituted or unsubstituted aryl group or has the formula —(CH2)n-φ, where φ is a substituted or unsubstituted phenyl group and n=0 to 6 to reduce melanin in the skin.
A method for whitening skin comprising applying to the skin a composition containing an effective amount of an active ingredient is selected from the group consisting of 4-diphenyl-2-hydroxytetronic acid, 4-(4′-chloro)phenyl-2-hydroxytetronic acid, 4-(1,1′-biphenyl)-2-hydroxytetronic acid, 4-(4-chloro-1,1′-biphenyl)-2-hydroxy-tetronic acid, and mixtures thereof, and at least one adjunct ingredient selected from the group consisting of tetronic acid or a tetronic acid ingredient, hydroquinone, an α-hydroxy acid, and a fatty acid ester of ascorbic acid to reduce melanin in the skin.
A method for whitening skin comprising topically administering to the skin an effective amount of a composition containing 4-diphenyl-2-hydroxytetronic acid to reduce melanin in the skin.
Dependencies are inferred from the claim text.