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US 7,019,022 B2Granted
Substituted tetrahydrocarbazole and cyclopentanoindole derivatives
AssigneeMerck Frosst Canada, Inc.
InventorsChristian Beaulieu, Daniel Guay, Zhaoyin Wang, Robert Zamboni
Life of this patent
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Abstract
The present invention provides substituted tetrahydrocarbazole and cyclopentanoindole derivatives as antagonists of DP receptor, and as such are useful for the treatment of prostaglandin D2 mediated diseases such as rhinitis, asthma and nasal congestion.
Claims11
A compound of the formula I:
- and pharmaceutically acceptable salts thereof, wherein n is 0 or 1;
- R1 is hydrogen or halogen;
- R2 is halogen, cyano, C1-3alkylsulfonyl or trifluoromethyl;
- and R3 is C1-3alkyl optionally substituted with 1–5 halogen atoms;
- and R4a and R4b are each hydrogen or one is hydrogen and the other is hydroxy, or both together represent oxo;
- with the proviso that when R1 is hydrogen, R2 is not 4-chloro.
3 more elements
Dependencies are inferred from the claim text.