Back to results
US 7,019,017 B2Granted
Small molecule inhibitors of HER2 expression
AssigneeBaylor College of Medicine
InventorsMotonari Uesugi, Shinichi Asada
Life of this patent
Estimating the term…
Abstract
Peptide mimetic small molecule inhibitors of Sur-2 are provided having the general formula:
Claims15
A compound of the formula:
- wherein R1 is an indole, substituted indole, alkyl, trihaloalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, non-aromatic heterocyclyl, hydroxy, alkoxy, aryloxy, mercapto, alkylthio, arylthio, sulfinyl, sulfonyl, carbonyl, cyano, nitro, halo, or amino;
- wherein R2 is a hydrogen, hydroxy, nitrate, halo, loweralkyl, or carbonyl;
- wherein R3 is a halo, loweralkyl, carbonyl, aryl, aralkyl, or heterocycle;
- and wherein R4 is adamantane, adamantane derivative, alkyl, trihaloalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, non-aromatic heterocyclyl, hydroxy, alkoxy, aryloxy, mercapto, alkylthio, arylthio, sulfinyl, sulfonyl, S-sulfonamido, N-sulfonamido, trihalomethane-sulfonamido, halo, carbonyl, cyano, nitro, halo, or amino;
- and wherein when R1 is an indole, R2 is a hydroxyl, and R3 is an isopropyl, R4 is not an adamantane;
- and pharmaceutically acceptable salts thereof.
3 more elements
A compound of the formula:
- wherein R1 and R2 are a hydrogen, halo, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, non-aromatic heterocyclyl, hydroxy, alkoxy, aryloxy, carbonyl, acetyl, carboxy, sulfonyl or trihalomethane-sulfonyl;
- and wherein R1 and R2 may be the same or different;
- and wherein R1 and R2 are not both hydrogen;
- and pharmaceutically acceptable salts thereof.
1 more element
A compound of the formula:
- wherein R1, R2, and R3 are a hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, non-aromatic heterocyclyl,, hydroxy, alkoxy, aryloxy, carbonyl, halo, acetyl, carboxy, sulfonyl or trihalomethane-sulfonyl;
- and wherein R1, R2, and R3 may be the same or at least one is different;
- and wherein R1, R2, and R3 are not all hydrogen;
- and pharmaceutically acceptable salts thereof.
1 more element
A compound of the formula:
- wherein R1 is a hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, non-aromatic heterocyclyl,, hydroxy, alkoxy, aryloxy, halo, carbonyl, acetyl, carboxy, sulfonyl or trihalomethane-sulfonyl.
A compound of the formula:
- wherein R1 is an alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, non-aromatic heterocyclyl, hydroxy, alkoxy, aryloxy, halo, carbonyl, acetyl, carboxy, sulfonyl or trihalomethane-sulfonyl;
- and wherein R1 is not isopropyl;
- and pharmaceutically acceptable salts thereof.
A compound of the formula:
A compound of the formula:
A compound of the formula:
Dependencies are inferred from the claim text.