Process for producing anticancer agent LL-D45042
AssigneeWyeth Holdings Corporation
InventorsValerie S. Bernan, Edmund I. Graziani
Life of this patent
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Abstract
The disclosure describes the production of anticancer agent LL-D45042, having the structure: by fermentation, to methods for the recovery and concentration of this anticancer agent from crude solutions, and to processes for the purification of this anticancer agent as well as a new microorganism of the species Streptomyces hygroscopicus LL-D45042 and mutants thereof useful in the preparation of this compound.
Claims3
A pharmaceutical composition comprising an effective amount of a compound having the structure
- together with a pharmaceutical acceptable carrier.
An anticancer agent LL-D45042 produced by the process which comprises aerobically cultivating a biologically pure culture of Streptomyces hygroscopicus LL-D45042 or a LL-D45042 producing mutant thereof in a sterile liquid medium containing assimilable sources of carbon, nitrogen and inorganic anion and cation salts until LL-D45042 is formed and recovering and isolating LL-D45042.
A process for the preparation of LL-D45042 comprising cultivating a biologically pure culture of Streptomyces hygroscopicus LL-D45042 or a LL-D45042 producing mutant thereof under aerobic conditions, in a sterile liquid medium containing assimilable sources of carbon, nitrogen and inorganic anion and cation salts, until LL-D45042 is formed;
- and recovering and isolating LL-D45042.
Dependencies are inferred from the claim text.