Aminoindazole derivatives as medicaments and pharmaceutical compositions including them

A compound of formula (I):

• wherein
• R3 is a (1–6C)alkyl, aryl, aryl(1–6C)alkyl, heteroaryl, heteroaryl(1–6C)alkyl, aryl or heteroaryl fused to a (1–10C) cycloalkyl, heterocycle, heterocycloalkyl, cycloalkyl, adamantyl, polycycloalkyl, alkenyl, alkynyl, CONR1R2, CSNR1R2, COOR1, SO2R1, C(═NH)R1 or C(═NH)NR1 radical;
• these radicals optionally being substituted by 1 or more substituents chosen from halogen, CN, NO2, NH2, OH, OR1, COOH, C(O)OR1, —O—C(O)R1, NR1R2, NHC(O)R1, C(O)NR1R2, SR1, S(O)R1, SO2R1, NHSO2R1, SO2NR1R2, C(S)NR1R2, NHC(S)R1, —O—SO2R1, —SO2—O—R1, aryl, heteroaryl, heterocycle, formyl, trifluoromethyl, trifluoromethylsulfanyl, trifluoromethoxy or (1–6C)alkyl;
• R5, R6 and R7 are, independently of one another, chosen from the following radicals:
• halogen, CN, NO2, NH2, OH, COOH, C(O)OR8, —O—C(O)R8, NR8R9, NHC(O)R8, C(O)NR8R9, NHC(S)R8, C(S)NR8R9, SR8, S(O)R8, SO2R8, NHSO2R8, SO2NR8R9, —O—SO2R8, —SO2—O—R8, trifluoromethyl, trifluoromethoxy, (1–6C)alkyl, (1–6C)alkoxy, aryl, aryl(1–6C)alkyl, heteroaryl, heteroaryl(1–6C)alkyl, heterocycle, cycloalkyl, alkenyl, alkynyl, adamantyl or polycycloalkyl;
• these radicals optionally being substituted by 1 or more substituents chosen from halogen, CN, NO2, NH2, OH, OR10, COOH, C(O)OR10, —O—C(O)R10, NR10R11, NHC(O)R10, C(O)NR10R11, NHC(S)R10, C(S)NR10R11, SR10, S(O)R10, SO2R10, NHSO2R10, SO2NR10R11, —O—SO2R10, —SO2—O—R10, aryl, heteroaryl, formyl, trifluoromethyl, trifluoromethoxy or (1–6C)alkyl;
• R1, R2, R8, R9, R10 and R11 are, independently of one another, a hydrogen, (1–6C)alkyl, aryl, alkenyl, alkynyl, heteroaryl, themselves optionally being substituted by 1 or more substituents chosen from halogen, (1–6C)alkyl, (1–6C)alkoxy, CN, NO2, NH2, OH, COOH, COOalkyl, CONH2, formyl, trifluoromethyl, trifluoromethoxy;
• R1 and R2 or R8 and R9 or R10 and R11 can form a 5- or 6-membered ring which may or may not have a heteroatom, such as O, S or N;
• and, when R3 is a 6-membered nitrogenous heteroaryl or a thiazolyl or an imidazolyl or an oxazolyl, then at least one of the R5 and R6 groups is an aryl which is optionally substituted by 1 or more substituents selected from halogen, CN, NO2, NH2, OH, OR10, COOH, C(O)OR10, —O—C(O)R10, NR10R11, NHC(O)R10, C(O)NR10R11, NHC(S)R10, C(S)NR10R11, SR10, S(O)R10, SO2R10, NHSO2R10, SO2NR10R11, —O—SO2R10, —SO2—O—R10, aryl, heteroaryl, formyl, trifluoromethyl, trifluoromethoxy and (1–6C)alkyl;
• its racemates, enantiomers or diastereoisomers and their mixtures, its tautomers and its pharmaceutically acceptable salts.