Peptide deformylase inhibitors

A compound according to Formula (1):

• wherein:
• R represents:
• C2-6 alkyl (optionally substituted by alkoxy, halogen, or C1-3 alkylsulfanyl), C2-6 alkenyl (optionally substituted by alkoxy, halogen, or C1-3 alkylsulfanyl), C2-6 alkynyl (optionally substituted by alkoxy, halogen, or C1-3 alkylsulfanyl), (CH2)n—C3-6, carbocycle (optionally substituted by alkoxy, halogen, or C1-3 alkylsulfanyl), (CH2)n—R4 {where R4 is phenyl, furan, benzofuran, thiophene, benzothiophene, tetrahydrofuran, tetrahydropyran, dioxane, 1,4-benzodioxane or benzo[1,3]dioxole;
• R4 is optionally substituted by one or more Cl, Br, I, C1-3 alkyl (optionally substituted by one to three F) or C1-2 alkoxy (optionally substituted by one to three F)};
• R1 represents:
• hydrogen, C1-6 alkyl (optionally substituted by hydroxy, halogen, amino, guanidino, phenyl, pyridyl, pyrrolyl, indolyl, imidazolyl, furanyl, benzofuranyl, piperidinyl, morpholinyl, quinolinyl, piperazinyl or dimethylaminophenyl) or (CH2)n—C3-7 carbocycle;
• R2 represents:
• hydrogen (provided that X is not O), C1-3 substituted alkyl, C2-3 substituted alkenyl, C2-3 substituted alkynyl, (CH2)n—C3-6 substituted carbocycle, aryl, heteroaryl, heterocyclic, carboxy (provided that X is not NR3 or O) or aminocarbonyl (provided that X is not NR3 or O);
• R3 represents:
• hydrogen, C1-3 substituted alkyl, phenyl, or may be taken together with R2 and the nitrogen atom to which they are attached to form an optionally substituted heterocyclic ring which is optionally fused to an aryl, a heteroaryl, or a second heterocyclic ring;
• X represents O, NR3 or a covalent bond;
• Y represents O, CH2 or a covalent bond;
• n=0-2;
• or a salt, solvate, or physiologically functional derivative thereof.