Tricyclic 6-alkylidene-penems as β-lactamase inhibitors
AssigneeWyeth
InventorsAranapakam Mudumbai Venkatesan, Tarek Suhayl Mansour, Takao Abe, Ado Mihira, Atul Agarwal, Hideki Ushirogochi, Yansong Gu, Satoshi Tamai, Fuk-Wah Sum
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Abstract
The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof. wherein one of A and B denotes hydrogen and the other an optionally substituted fused tricyclic heteroaryl group; and X is S.
Claims44
A compound of formula I
- wherein:
- one of A and B denotes hydrogen and the other an optionally substituted fused tricyclic heteroaryl group;
- X is S;
- R5 is H, C1–C6 alkyl, C5–C6 cycloalkyl, or CHR3OCOC1–C6alkyl;
- and
- R3 is hydrogen, C1–C6 alkyl, C5–C6 cycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl;
- or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof.
A method for the treatment of bacterial infection or disease in a patient in need thereof which comprises providing to said patient an effective amount of a compound of formula I:
- wherein:
- one of A and B denotes hydrogen and the other an optionally substituted fused tricyclic heteroaryl group;
- X is S;
- R5 is H, C1–C6 alkyl, C5–C6 cycloalkyl, or CHR3OCOC1–C6alkyl;
- and
- R3 is hydrogen, C1–C6 alkyl, C5 –C6 cycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl;
- or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof.
Dependencies are inferred from the claim text.