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US 7,018,995 B2Granted
Carbonate and carbamate modified forms of glucocorticoids
AssigneeSepracor Inc.
InventorsMark G. Currie, Steve Jones, Paul Grover, Chris H. Senanayake, Q. Kevin Fang
Life of this patent
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Abstract
Carbonates and carbamates of the formula and related steroid carbonates and carbamates are disclosed. The compounds are useful for treating rhinitis and asthma, particularly by inhalation, and for treating inflammation, particularly by local or topical administration.
Claims23
A compound of Formula I:
- wherein
- R1 and R2, independently for each occurrence, represent lower alkyl or lower acyl, or taken together R1 and R2 form a substituted or unsubstituted ketal;
- R3 is —OR4 or —NR5R6;
- R4 is chosen from C7 to C24 hydrocarbon, —(C7 to C24 hydrocarbon)-COOH and —(C7 to C24 hydrocarbon)-NR9R10;
- R5 is hydrogen or C7 to C24 hydrocarbon;
- R6 is chosen from C7 to C24 hydrocarbon and —(C7 to C24 hydrocarbon)-COOH;
- R9 is hydrogen or C1 to C17 hydrocarbon;
- R10 is hydrogen or C1 to C17 hydrocarbon;
- R11 is methyl or —OR2;
- and
- X and y are independently hydrogen or halogen.
8 more elements
Dependencies are inferred from the claim text.