Human N-type calcium channel isoform and uses thereof
AssigneeBrown University Research Foundation
InventorsDiane Lipscombe, Stephanie Schorge
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Abstract
The invention pertains to a human N-type calcium channel isoform, hα1B+SFVG, which is involved in central nervous system signaling, and nucleic acids relating thereto. The present invention also includes fragments and biologically functional variants of the human hα1B+SFVG channel. Also included are human N-type calcium channel hα1B+SFVG subunit inhibitors which inhibit human N-type calcium channel hα1B+SFVG subunit activity by inhibiting the expression or function of human N-type calcium channel hα1B+SFVG subunit. The invention further relates to methods of using such nucleic acids, polypeptides, and inhibitors in the treatment and/or diagnosis of disease, such as in methods for treating stroke, pain, e.g., neuropathic pain, and traumatic brain injury.
Claims7
An isolated human N-type calcium channel hα1B+SFVG subunit nucleic acid molecule which encodes a human N-type calcium channel hα1B+SFVG subunit polypeptide comprising SEQ ID NO:4.
An isolated human N-type calcium channel hα1B+SFVG subunit nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:3.
An isolated human N-type calcium channel hα1B+SFVG subunit nucleic acid molecule consisting of the nucleotide sequence of SEQ ID NO:3.
Dependencies are inferred from the claim text.