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US 7,018,826 B1Granted
Particles for gene therapy
AssigneeIsland Pharmaceuticals, Ltd.
InventorsEberhard Hildt, Peter Hofschneider
Life of this patent
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Abstract
The present invention relates to particles, comprising: a protein envelope with a fusion protein, which comprises a virus protein, a cell permeability-mediating peptide and a heterologous cell-specific binding site; and a nucleic acid present in the protein envelope, which comprises the sequence for a virus-specific packaging signal and a structural gene. The invention further relates to methods for the preparation of such particles and means suitable for this purpose, as well as the use of the particles in gene therapy.
Claims10
A particle comprising:
- (a) a protein envelope with a fusion protein, the fusion protein comprising a virus protein, a cell permeability-mediating peptide, and a heterologous cell-specific binding site;
- and
- (b) nucleic acid sequences present within the protein envelope, each of the nucleic acid sequences comprising a sequence encoding a virus-specific packaging signal and a sequence encoding a structural gene, wherein the cell permeability-mediating peptide comprises the amino acid sequence set forth in SEQ ID NO:20.
A particle comprising:
- (a) a protein envelope with a fusion protein, the fusion protein comprising a virus protein, a cell permeability-mediating peptide, and a heterologous cell-specific binding site;
- and
- (b) nucleic acid sequences present within the protein envelope, each of the nucleic acid sequences comprising a sequence encoding a virus-specific packaging signal and a sequence encoding a structural gene, wherein the fusion protein consists of the amino acid sequence set forth in SEQ ID NO:1.
A particle comprising:
- (a) a protein envelope with a fusion protein, the fusion protein comprising a virus protein, a cell permeability-mediating peptide, and a heterologous cell-specific binding site;
- and
- (b) nucleic acid sequences present within the protein envelope, each of the nucleic acid sequences comprising a sequence encoding a virus-specific packaging signal and a sequence encoding a structural gene, wherein the fusion protein consists of the amino acid sequence set forth in SEQ ID NO:2.
Dependencies are inferred from the claim text.