Chordin-like molecules and uses thereof
AssigneeAmgen Inc.
InventorsNaoki Nakayama, Duanzhi Wen, Chun-Ya Han, Ching He, Dongyin Yu
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Abstract
The present invention provides Chordin-Like (CHL) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing CHL polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with CHL polypeptides.
Claims17
An isolated polynucleotide, comprising nucleotides 195-1487 of SEQ ID NO:7.
An isolated polynucleotide, comprising nucleotides 186-1487 of SEQ ID NO:7.
An isolated polynucleotide, comprising nucleotides 132-1487 of SEQ ID NO:7.
An isolated polynucleotide that encodes a polypeptide comprising amino acids 22-452 of SEQ ID NO:8.
An isolated polynucleotide that encodes a polypeptide comprising amino acids 18-452 of SEQ ID NO:8.
An isolated polynucleotide that encodes a polypeptide comprising amino acids 1-452 of SEQ ID NO:8.
An isolated polynucleotide that encodes a polypeptide comprising amino acids 22-452 of SEQ ID NO:8, wherein the polypeptide has an amino- or carboxy-terminus truncation such that the polypeptide retains the capacity to bind Bone Morphogenetic Protein-4 (BMP-4).
An isolated polynucleotide comprising the nucleotide sequence of the DNA insert in ATCC Deposit No. PTA-963.
An isolated polynucleotide, comprising a nucleotide sequence that is complementary over the full length of nucleotides 132-1487 of SEQ ID NO:7.
An isolated polynucleotide, comprising a nucleotide sequence that is complementary over the full length of nucleotides 186-1487 of SEQ ID NO:7.
An isolated polynucleotide, comprising a nucleotide sequence that is complementary over the full length of nucleotides 195-1487 of SEQ ID NO:7.
Dependencies are inferred from the claim text.