Method for treating neurodegenerative disorders
AssigneeOrtho-McNeil Pharmaceutical, Inc.
InventorsAllen B. Reitz, David A. Demeter, Daniel H. S. Lee, Hoau-Yan Wang, Robert H. Chen, Tina Morgan Ross, Malcolm K. Scott, Carlos R. Plata-Salaman
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Abstract
The invention is directed to a method of treating a neurodegenerative disorder in a subject in need thereof which comprises administering to the subject an amount of a compound effective to inhibit the interaction of amyloid-beta with alpha-7 nicotinic acetylcholine receptors.
Claims8
A method for identifying compounds which are useful for the treatment of neurodegenerative disorders comprising testing compounds for their ability to block the interaction of a peptide selected from the group consisting of 125I-Aβ1-40, Aβ1-40 and Aβ1-42 with nicotine acetylcholine receptors.
A method for the identification of compounds that block the interaction of an alpha-7 nicotine acetylcholine receptor or peptide fragment thereof with an amyloid beta peptide or fragment thereof comprising
- (a) contacting the compound to be tested with an amyloid beta peptide or fragment thereof and alpha-7 nicotine acetylcholine receptor or peptide fragment thereof;
- (b) determining the extent to which the compound blocks the interation of the alpha-7 nicotine acetylcholine receptor or peptide fragment thereof with the amyloid beta peptide or fragment thereof.
Dependencies are inferred from the claim text.