Particulate composition
AssigneeUniversity College Cardiff Consultants Limited
InventorsPaul Alfred Dickinson, Ian Walter Kellaway, Stephen Wyn Howells
Life of this patent
Estimating the term…
Abstract
Nanoparticles are prepared from a colloidal system comprising a continuous phase and micelles, the micelles comprising surfactant material. A microemulsion is formed by admixing the colloidal system with a solution of an active material, such as a medicament, dissolved in a solvent wherein the solution forms a disperse phase with the micelles of surfactant material. At least the dispersed phase is quenched to a solid state and the continuous phase and solvent are removed to produce the nanoparticles. The nanoparticles can be incorporated in an aerosol composition suitable for deep lung delivery by means of a metered dose inhaler.
Claims20
A method for preparing a particulate composition comprising particles having an average diameter within the range of from about 1 nm to less than about 1000 nm, wherein the method comprises:
- (i) forming a colloidal system comprising a continuous phase and micelles, the micelles comprising surfactant material;
- (ii) forming a microemulsion by admixing the colloidal system of step (i) with a solution of a medicament dissolved in a solvent, wherein the solution forms a disperse phase within the micelles of surfactant material;
- (iii) quenching at least the disperse phase to a solid state;
- and
- (iv) removing the continuous phase and the solvent so as to yield the particles.
Dependencies are inferred from the claim text.