Amphiphilic diblock, triblock and star-block copolymers and their pharmaceutical compositions
AssigneeLabopharm, Inc.
InventorsBhalchandra Shripad Lele, Jean-Christophe Leroux
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Abstract
This invention relates to novel amphiphilic diblock, triblock copolymers and star-shaped block copolymers comprising a biodegradable polymer covalently attached at the polymer ends, to a hydrophilic vinyl polymer, via divalent sulfur atom; to a process for producing the block polymers; to a polymerization process which comprises subjecting the monomers capable of radical polymerization to radical polymerization in the presence of a macromolecular biodegradable chain-transfer agent; and to pharmaceutical compositions comprising the block copolymers loaded with therapeutic agents.
Claims8
A therapeutic composition consisting of:
- an amphiphilic diblock, triblock or star-shaped block copolymer formed by a biodegradable polymer selected from the group consisting of a polyester, a polyamide, a poly(ester-amide), a polyanhydride and combinations thereof, being covalently attached at the polymer ends to at least one hydrophilic vinyl polymer by way of a divalent sulfur atom;
- and
- an effective amount of at least one therapeutic agent;
- wherein said therapeutic composition is characterized by its ability to form a nanodispersion or micelle in aqueous media.
A therapeutic composition consisting of:
- an amphiphilic diblock, triblock or star-shaped block copolymer formed by a biodegradable polymer selected from the group consisting of a polyester, a polyamide, a poly(ester-amide), a polyanhydride and combinations thereof, being covalently attached at the polymer ends to at least one hydrophilic vinyl polymer by way of a divalent sulfur atom;
- and an effective amount of at least one therapeutic agent;
- and at least one targeting moiety conjugated to pendant functional groups in said at least one hydrophilic vinyl polymer;
- wherein said therapeutic composition is characterized by its ability to form a nanodispersion or micelle in aqueous media.
Dependencies are inferred from the claim text.