US 7,018,654 B2 · Pharmaceutical composition containing an active agent in an amino acid copolymer structure

Abstract

A method of protecting a chemical compound from degradation comprising combining the chemical compound with an amino acid polymer. Disclosed are methods of combining chemical compounds with synthetic amino acid polymers for protection from degradation of the chemical compounds and to provide for controlled release of the compounds. A method is described for the selective release of drug substances from a synthetic amino acid polymer in the stomach or small intestine, utilizing pH-dependent changes in a higher order structure. A pharmaceutical composition comprising a drug substance that has been combined with an amino acid polymer and a pharmaceutically acceptable combination of excipients is disclosed. A cell culture media comprising a polypeptide containing glutamine that has been co-polymerized with an amino acid is described.

Claims26

Dependent claims

A pharmaceutical composition comprising:

(i) an active agent non-covalently linked in an internalized domain or pocket of an amino acid copolymer structure wherein said amino acid copolymer structure comprises at least one hydrophilic component and at least one hydrophobic component designed to promote the formation of said internalized domain or pocket;
and
(ii) said hydrophilic component and hydrophobic component are selected to manipulate the tertiary structure of said amino acid copolymer structure to control degradation and release of said active agent;
wherein said hydrophilic component is lysine, arginine, asparagine, cysteine, glutamic acid or combinations thereof;
wherein said hydrophobic component is valine, tyrosine, proline, leucine, tryptophan, methionine, phenylalanine, glycine, isoleucine, benzyl glutamic acid, or combinations thereof;
and
wherein said composition is in a form suitable for oral administration.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application

09/986,426Filed 8 Nov 2001 · continuation in part

Priority

5 Mar 1999

Published

US 2002/0128177 A112 Sep 2002

Granted

28 Mar 2006

Term ends

Not estimatedThe source records don’t support an estimate.

Classification8 codes

C08G 69/10
Derived from amino-carboxylic acids: alpha-amino-carboxylic acids
A61K 9/146
Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried,…: with…
A61K 9/2045
Obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers:…
A61K 47/34
Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates: macromolecular compounds obtained otherwise than by reactions only…

Family

Application60/123,146Us provisional application · filed 5 Mar 1999

Application09/265,415Parent of this continuation-in-part · filed 10 Mar 1999

Application09/411,238Parent of this continuation-in-part · filed 4 Oct 1999

PCT/US00/05693Parent of this continuation-in-part · filed 6 Mar 2000

US 2002/0128177 A1Pre-grant publication · published 12 Sep 2002

Application09/959,396Parent of this continuation-in-part

US 7,018,654 B2This patent

From the US filing history. Foreign family members aren’t listed.

Pharmaceutical composition containing an active agent in an amino acid copolymer structure

Life of this patent

Pharmaceutical composition containing an active agent in an amino acid copolymer structure

Life of this patent

Abstract

Claims26