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US 7,018,653 B2Granted
Method for preparing solid dosage form of desmopressin
AssigneeFerring B.V.
InventorsKristen Wannerberger, Hans Lindner, Lars-Erik Olsson, Ann Elisabeth Svensson
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Abstract
The present invention relates to a novel method for the preparation of a solid dosage form of desmopressin, or a pharmaceutically acceptable salt thereof, comprising providing a desmopressin containing granulate suitable for compression to a pharmaceutically acceptable tablet, as well as to solid dosage forms, preferably tablets, obtainable by said method.
Claims14
A method for the preparation of a solid dosage form of desmopressin acetate, comprising:
- (a) providing a powder comprising at least one excipient, carrier or diluent, or mixture thereof;
- (b) providing a granulation liquid comprising a solvent, a binder, and desmopressin acetate, and
- (c) contacting said granulation liquid with said powder within a fluid bed granulation apparatus and selecting fluidising air flow and processing temperature and time to provide mixing and shearing action to form a granulate,
- wherein said granulate is suitable for compression to a pharmaceutically acceptable tablet, and
- wherein said method provides a solid dosage form comprising an amount of desmopressin acetate of from 20 to 600 μg per unit.
2 more elements
Dependencies are inferred from the claim text.