Patches for external use
AssigneeTeikoku Seiyaku Co., Ltd.
InventorsKeiko Yamasaki, Mitsuji Akazawa, Jutaro Shudo, Keiji Nozaki
Life of this patent
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Abstract
In order to provide an external skin patch having improved painkilling effect for pains accompanied by inflammation, such as chronic arthrorheumatism, arthrosis deformans or low back pain, an external skin patch is obtained by coating a drug-containing base on a substrate; the drug-containing base comprises an adhesive gel base containing a water soluble polymeric material, a crosslinking agent, water and a humectant as essential components, and a local anesthetic and a nonsteroidal antiphlogistic analgesic agent as medicinal components.
Claims5
An external skin patch, comprising a substrate and a drug reservoir layer coated on the substrate, in which the drug reservoir layer comprises (1) an adhesive gel base which comprises a water soluble polymeric material, a crosslinking agent, 20 to 60% by weight of water based upon the total weight of the adhesive gel base and a humectant as essential components, together with (2) medicinal components comprising a local anesthetic and a nonsteroidal antiphlogistic analgesic agent, wherein the crosslinking agent is selected from the group consisting of aluminum compounds, wherein the humectant is selected from the group consisting of polyhydric alcohols, saccharides and superabsorbent resins, wherein the local anesthetic is selected from the group consisting of tetracaine, procaine, dibucaine, benzocaine, xylocaine, and pharmaceutically acceptable salts thereof, and wherein the nonsteroidal antiphlogistic analgesic agent is selected from the group consisting ketoprofen, piroxicam, felbinac, bufexamac, suprofen, flurbiprofen, ibuprofen, and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.