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US 7,018,626 B2Granted
Chimeric IL-10
AssigneeBeth Israel Deaconess Medical Center, Inc.
InventorsTerry B. Strom, Xin Xiao Zheng, Alan Steele
Life of this patent
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Abstract
Disclosed are chimeric proteins having a cytokine fused to an enzymatically inactive polypeptide which increases the circulating half-life of the cytokine. The chimeric proteins are useful for treating, inhibiting, or preventing a variety of conditions, including septic shock, granulomatous disorders, Type I diabetes, and various cancers (e.g., multiple myeloma) in a patient.
Claims15
A chimeric protein comprising interleukin-10 (IL-10) and a polypeptide that increases the circulating half-life of the chimeric protein comprising IL-10 relative to that of IL-10 alone.
Dependencies are inferred from the claim text.