Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
AssigneeDebio Recherche Pharmaceutique S.A.
InventorJ. Milton Harris
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Abstract
A degradable PEG hydrogel is described that, upon hydrolysis, releases conjugates of substantially non-peptidic polymers and biologically active molecules. For example, PEG and protein conjugates can be released in vivo from the hydrogels for therapeutic application.
Claims27
A degradable crosslinked polymer structure, comprising a poly(ethylene glycol) molecule covalently attached to a biologically active molecule and having at least one hydrolytically unstable linkage in its backbone, and a branched, substantially non-peptidic polymer crosslinked to the poly(ethylene glycol) molecule, wherein the hydrolytically unstable linkage in the backbone of the poly(ethylene glycol) molecule is capable of degrading in aqueous solution to release a conjugate of the biologically active molecule and poly(ethylene glycol).
A degradable crosslinked polymer structure, comprising a first poly(ethylene glycol) molecule covalently attached to a biologically active molecule and having at least one hydrolytically unstable linkage in its backbone, and a second branched poly(ethylene glycol) crosslinked to the first poly(ethylene glycol) molecule, wherein the hydrolytically unstable linkage in the backbone of the first poly(ethylene glycol) molecule is capable of degrading in aqueous solution to release a conjugate of the biologically active molecule and poly(ethylene glycol), and wherein the second branched poly(ethylene glycol) does not have hydrolytically unstable linkages in its backbone.
A degradable crosslinked polymer structure, comprising a first poly(ethylene glycol) molecule covalently attached to a biologically active molecule through a hydrolytically stable linkage and having at least one hydrolytically unstable ester linkage in its backbone, and a second branched poly(ethylene glycol) crosslinked to the first poly(ethylene glycol) molecule, wherein the hydrolytically unstable ester linkage in the backbone of the first poly(ethylene glycol) molecule is capable of degrading in aqueous solution to release a conjugate of the biologically active molecule and poly(ethylene glycol), and wherein the second branched poly(ethylene glycol) does not have hydrolytically unstable linkages in its backbone.
Dependencies are inferred from the claim text.