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US 7,018,620 B2Granted
Delivery of beta-blockers through an inhalation route
AssigneeAlexza Pharmaceuticals, Inc.
InventorsJoshua D. Rabinowitz, Alejandro C. Zaffaroni
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AssigneeAlexza Pharmaceuticals, Inc.
InventorsJoshua D. Rabinowitz, Alejandro C. Zaffaroni
Estimating the term…
The present invention relates to the delivery of atenolol, pindolol, esmolol, propranolol, or metoprolol through an inhalation route. Specifically, it relates to aerosols containing atenolol, pindolol, esmolol, propranolol, or metoprolol that are used in inhalation therapy. In a method aspect of the present invention, atenolol, pindolol, esmolol, propranolol, or metoprolol is administered to a patient through an inhalation route. The method comprises: a) heating a composition of atenolol, pindolol, esmolol, propranolol, or metoprolol, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles with less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering atenolol, pindolol, esmolol, propranolol, or metoprolol through an inhalation route is provided which comprises: a) a thin coating of an atenolol, pindolol, esmolol, propranolol, or metoprolol composition and b) a device for dispensing said thin coating as a condensation aerosol.
A method of treating hypertension, acute myocardial infarction, cardiac arrhythmias or side effects of situational anxiety in a patient comprising administering a therapeutic amount of a drug condensation aerosol to the patient by inhalation,
A method of administering a drug condensation aerosol to a patient comprising administering the drug condensation aerosol to the patient by inhalation,
A kit for delivering a drug condensation aerosol comprising:
The kit according to claim 33, wherein the condensation aerosol is characterized by an MMAD of about 0.2 to about 3 microns.
Dependencies are inferred from the claim text.