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US 7,018,617 B1Granted
Methods and compositions associated with nociceptive pain
AssigneeCalifornia Institute of Technology
InventorsWilliam Daniel Tracey, Jr., Seymour Benzer
Life of this patent
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Abstract
Provided are methods and compositions corresponding to a genetic locus associated with nociceptive pain. In addition, method of identifying or modulating nociceptive pain and associated disorders is also provided.
Claims5
A method of identifying an agent that modulates a nociceptive reflex response comprising:
- (a) contacting a Drosophila melanogaster organism having an endogenous polynucleotide encoding a polypeptide as set forth in SEQ ID NO:2 with an agent suspected of having nociceptive pain reflex modulating activity;
- and
- (b) comparing the expression of the polynucleotide in the presence of the agent to the expression of the polynucleotide in the absence of the agent, wherein a difference in expression is indicative of an agent that modulates a nociceptive pain reflex response.
Dependencies are inferred from the claim text.