Stabilization of radiopharmaceuticals labeled with 18-F
AssigneeEastern Isotopes, Inc.
InventorsMaxim Y. Kiselev, Vincent Tadino
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Abstract
An 18F isotope-labeled FDG radiopharmaceutical is stabilized against degradation in radiochemical purity due to radiolysis using selected amounts of ethyl alcohol that depend on the activity concentration of the 18F with due regard to limits set by various pharmacopoeia standards. Any of the well-know production methods for the FDG may be used and the ethyl alcohol added at several stages, preferably as part of the standard hydrolysis step. This particular radiopharmaceutical is used extensively in diagnostic imaging with a Positron Emission Tomography technique.
Claims16
A radiopharmaceutical composition comprising:
- 18F isotope-labeled FDG in water having an activity concentration;
- and
- ethanol with a final product concentration having a minimum of 0.1% (v/v).
A process for preparing an 18F isotope-labeled FDG radiopharmaceutical composition in water comprising a nucleophilic 18F fluorination step followed by a hydrolysis step and the step of adding ethanol with a minimum concentration of about 0.1% (v/v) in the final product.
Dependencies are inferred from the claim text.