Preparations for evaluating eliminative ability of stomach
AssigneeOtsuka Pharmaceutical Co., Ltd.
InventorsShinsuke Nakagawa, Keigo Yamada, Masateru Miyake, Makoto Inada, Nobuhiro Ikei, Atsunari Noda, Hideji Nonomura
Life of this patent
Estimating the term…
Abstract
Preparations whereby reduction or acceleration of the gastric emptying rate can be noninvasively evaluated: and a method of evaluating the gastric emptying rate by using these preparations. Thus, reduction or acceleration of the gastric emptying rate can be safely and conveniently examined. Namely, theses preparations are useful in objectively diagnosing the gastric motor function, as well as in evaluating and judging the drug effect or therapeutic effect of a drug concerning the gastric motor function on individual patients.
Claims20
A preparation for measuring the gastric emptying rate comprising a composition containing a compound that is labeled with at least one of the isotopes of C and O and that is converted into labeled CO2 in the body and excreted in the exhalation,
- the preparation being coated by an enteric coating and having a mean size of 1 mm or greater, wherein the behavior of the preparation following oral administration to a subject being such that:
- (1) the preparation remains inside the stomach after entering the stomach, without being discharged from the stomach,
- (2) the preparation is discharged from the stomach by the gastric housekeeper movement, and
- (3) the preparation is dissolved in the intestines, and the labeled compound eluted from the interior of the preparation is converted into labeled carbon dioxide inside the intestines or absorbed and metabolized, and is excreted in the exhalation.
A preparation for measuring the gastric emptying rate comprising a composition containing a compound that is labeled with at least one of the isotopes of C and O and that is converted into labeled CO2 in the body and excreted in the exhalation, the preparation being coated by an enteric coating that dissolves in the intestines and having a mean size of 2 mm or smaller, wherein the behavior of the preparation following oral administration to a subject being such that:
- (1) the preparation enters the stomach,
- (2) the preparation is discharged from the stomach by the gastric movement to discharge food, and
- (3) the preparation is dissolved in the intestines, and the labeled compound eluted from the interior of the preparation is converted into labeled carbon dioxide inside the intestines or absorbed and metabolized, and is excreted in the exhalation.
A preparation for measuring the gastric emptying rate comprising a composition containing a compound that is labeled with at least one of the isotopes of C and O and that is converted into labeled CO2 in the body and excreted in the exhalation, the preparation being coated by an enteric coating and having a mean size of 2 mm or greater, wherein the behavior of the preparation following oral administration to a subject being such that:
- (1) the preparation remains inside the stomach after entering the stomach, without being discharged from the stomach,
- (2) the preparation is discharged from the stomach by the gastric housekeeper movement, and
- (3) the preparation is dissolved in the intestines, and the labeled compound eluted from the interior of the preparation is converted into labeled carbon dioxide inside the intestines or absorbed and metabolized, and is excreted in the exhalation.
A preparation for measuring the gastric emptying rate comprising a composition containing a compound that is labeled with at least one of the isotopes of C and O and that is converted into labeled CO2 in the body and excreted in the exhalation, the preparation being coated by an enteric coating that dissolves in the intestines and having a mean size of 1 mm or smaller, wherein the behavior of the preparation following oral administration to a subject being such that:
- (1) the preparation enters the stomach,
- (2) the preparation is discharged from the stomach by the gastric movement to discharge food, and
- (3) the preparation is dissolved in the intestines, and the labeled compound eluted from the interior of the preparation is converted into labeled carbon dioxide inside the intestines or absorbed and metabolized, and is excreted in the exhalation.
Dependencies are inferred from the claim text.