Method of preparing a radioactive rhenium complex solution
AssigneeMallinckrodt Inc.
InventorsHelena Panek-Finda, David W. Pipes
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Abstract
The invention relates to a method of preparing a solution of a radioactive rhenium complex, by reacting at elevated temperature a radioactive perrhenate in a substantially aqueous solution with a ligand in the presence of a reductant and optionally an antioxidant under substantially anaerobic conditions, wherein said reaction is carried out at a pH from approx. 1.5 to approx. 5 and by heating the reaction components for at least 10 min. at a temperature of at least 100° C. The invention further relates to a kit for performing said method.
Claims15
A method for preparing a sterile radiopharmaceutical composition comprising:
- preparing a solution of a radioactive rhenium complex;
- sterilizing the solution by autoclaving the solution for a period of time sufficient to render the solution sterile;
- and
- adjusting the pH of the sterile solution to a range of about 4 to about 9 by addition of a sterile buffer solution under an inert atmosphere.
A method of preparing a sterile radiopharmaceutical composition comprising the steps of:
- preparing a radioactive rhenium complex solution;
- adjusting the pH of the solution to a range of about 5 to about 6;
- sterilizing the pH adjusted solution by autoclaving for a period of time sufficient to render the solution sterile;
- and
- storing the sterilized solution for a period of about 3 hours before administration of the solution.
Dependencies are inferred from the claim text.