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US 7,018,599 B2Granted
Fullerene derivatives
AssigneeAstellas Pharma Inc.
InventorsEiichi Nakamura, Masaya Sawamura, Hiroyuki Isobe
Life of this patent
Estimating the term…
Abstract
A novel means for DNA compaction is provided. The object is accomplished by providing a fullerene derivative having 1 to 4 nitrogen-containing hydrophilic side chain(s) or its salt for DNA compaction. DNA compaction can be achieved effectively, and application to gene therapy is also expected.
Claims6
A fullerene derivative of the following general formula or a salt thereof:
- wherein the two Rs may be the same or different and each represents a straight-chain or branched-chain acyl group comprising 1 to 10 nitrogen atoms and 2 to 30 carbon atoms or hydrogen,
- with the provisos that:
- (1) the two Rs are not both hydrogen;
- (2) said fullerene derivative does not have the following formula:
1 more element
A fullerene derivative of the following general formula or a salt thereof:
- wherein R represents a straight-chain or branched-chain acyl group comprising 1 to 10 nitrogen atoms and 2 to 30 carbon atoms and R′ represents hydrogen or a lower alkyl group,
- with the proviso that said fullerene derivative does not have the following formula:
Dependencies are inferred from the claim text.