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US 7,018,460 B2Granted
Self-hardening calcium phosphate materials with high resistance to fracture, controlled strength histories and tailored macropore formation rates
AssigneeAmerican Dental Association Health Foundation
InventorsHuakun Xu, Laurence C. Chow, Shozo Takagi, Frederick C. Eichmiller
Life of this patent
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Abstract
A bone replacement material and therapy comprises the combination of calcium phosphate compounds and two or more soluble fillers in the form of fibers, mesh or other materials which have the dual functions of reinforcing an in vivo implant while dissolving at a programmed rate to form macropores capable of receiving natural bone ingrowth.
Claims6
A bone and hard tissue replacement material comprising, in combination, a mixture of:
- a calcium phosphate compound capable of forming a chemically compatible in vivo bone or hard tissue replacement composition;
- and
- at least first and second macropore forming materials, said first and second macropore forming materials each have a dissolution rate in vivo, at least one of said macropore forming materials characterized by increasing the flexural strength of said mixture in vivo by at least about 50%, said macropore forming materials generally soluble in vivo and insoluble in said calcium phosphate compound.
Dependencies are inferred from the claim text.