Intravascular delivery of methylprednisolone
AssigneeAvantec Vascular Corporation
InventorsMotasim Sirhan, John Yan
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Abstract
The present invention provides improved devices and methods for minimizing and/or inhibiting restenosis and hyperplasia after intravascular intervention. In particular, the present invention provides luminal prostheses which allow for programmed and controlled methylprednisolone delivery with increased efficacy to selected locations within a patient's vasculature to inhibit restenosis. An intraluminal delivery prosthesis may comprise an expansible structure and means on or within the structure for releasing methylprednisolone into the body lumen to inhibit smooth muscle cell proliferation.
Claims28
A method for inhibiting restenosis in a blood vessel following recanalization of the blood vessel, said method comprising:
- implanting a vascular prosthesis in the blood vessel;
- and
- releasing methylprednisolone and mycophenolic acid from the prosthesis when implanted in the blood vessel.
A method for inhibiting restenosis in a blood vessel following recanalization of the blood vessel, said method comprising:
- implanting a vascular prosthesis in the blood vessel;
- and
- releasing methylprednisolone and mizoribine from the prosthesis when implanted in the blood vessel.
Dependencies are inferred from the claim text.