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US 7,015,200 B2Granted
Gamma-hydroxybutyrate compositions containing carbohydrate, lipid or amino acid carriers
AssigneeOrphan Medical, Inc.
InventorsMortimer Mamelak, William C. Houghton, Dayton T. Reardan, Brian L. Miller
Life of this patent
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Abstract
The present invention provides compositions comprising at least one GHB moiety bonded to at least one physiologically compatible carrier molecule. The compositions can enhance the uptake of the drug, deliver effective therapeutic doses in a time-delayed fashion, or can target specific organs.
Claims12
A compound of the formula (I):
- wherein Y is H, a (C4-C6)acetal, (C1-C5)acyl or (C1-C5)alkyl, X is a carbohydrate and n has a value of 1 to the number of available hydroxyl groups in said carbohydrate, or a pharmaceutically acceptable salt thereof.
A method for treating a mammal afflicted with a condition or pathology amenable to treatment by gamma-hydroxybutyrate (GHB) comprising administering to said mammal an effective amount of a compound of formula (I):
- wherein Y is H or a hydroxyl protecting group, X is a carbohydrate and n has a value of 1 to the number of available hydroxyl groups in said carbohydrate, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.