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US 7,015,047 B2Granted
Microdevices having a preferential axis of magnetization and uses thereof
AssigneeAviva Biosciences Corporation
InventorsMingxian Huang, Lei Wu, Xiaobo Wang, Junquan Xu, Guo Liang Tao, David M. Rothwarf
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Abstract
This invention relates generally to the field of moiety or molecule isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided.
Claims45
A microdevice, which microdevice comprises:
- a) a magnetizable substance;
- b) a photorecognizable coding pattern,
- wherein said microdevice has a preferential axis of magnetization,and wherein an induced magnetization in its absolute magnitude along the preferential axis of the magnetization of said microdevice is at least 20% more than an induced magnetization of said microdevice along at least one other axis, wherein said microdevice has a thin rectangular shape with the preferential axis of the magnetization substantially in the direction of the length of the microdevice, and
- i) wherein said microdevice comprises at least two rectangular structures of said magnetizable substance separated by a non-magnetizable metal layer, and said microdevice has unequal number of said magnetizable substance rectangular structures on each side of said non-magnetizable metal layer along major axis of said microdevice;
- or
- ii) two rectangular structures of the magnetizable substance along the major axis of the microdevice and at least one of the rectangular structures has fingers on both ends, and
- c) a binding partner that is capable of binding to a moiety on a surface of the microdevice.
4 more elements
Dependencies are inferred from the claim text.