Rate-reducing membrane for release of an agent
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorStephen D. Pacetti
Life of this patent
Estimating the term…
Abstract
A membrane that reduces the rate at which a therapeutic substance is released from an implantable medical device, such as a stent, is disclosed.
Claims65
A stent having a therapeutic agent, comprising:
- (a) a first coating or layer over a surface of a stent;
- (b) a second coating or layer comprising a polymer and an agent over the first coating or layer;
- and
- (c) a third coating or layer comprising a polymer over the second coating or layer, the polymer having a solubility parameter not greater than approximately 11.5 (cal/cm3)1/2 ,
- wherein the third coating or layer reduces the rate of release of the agent.
A stent having a therapeutic agent, comprising:
- (a) a first coating or layer comprising a polymer and an agent for a stent;
- and
- (b) a second coating or layer comprising a polymer over the first coating or layer, the polymer having a solubility parameter not greater than approximately 11.5 (cal/cm3)1/2, wherein the second coating or layer reduces the rate of release of the agent.
A stent having a therapeutic agent, comprising:
- (a) a first coating comprising a polymer and an agent for the stent;
- and
- (b) a second coating comprising a polymer over the first coating, the second coating having a solubility parameter not greater than a parameter selected from the group consisting of about 11.5 (cal/cm3)1/2, about 10 (cal/cm3)1/2, and about 8.5 (cal/cm3)1/2.
A stent comprising a coating having a first region including rapamycin and a second region above the first region, the second region including a polymer having a solubility parameter not greater than approximately 11.5 (cal/cm3)1/2.
A stent comprising a coating having a first region including docetaxel or paclitaxel and a second region above the first region, the second region including a polymer having a solubility parameter not greater than approximately 11.5 (cal/cm3)1/2 .
A stent comprising a radially expandable metallic body and a coating on the body, the coating having a first region including rapamycin and a second region above the first region, the second region having a solubility parameter not greater than approximately 11.5 (cal/cm3)1/2.
A stent comprising a radially expandable metallic body and a coating on the body, the coating having a first region including docetaxel or paclitaxel and a second region above the first region, the second region having a solubility parameter not greater than approximately 11.5 (cal/cm3)1/2.
A method of forming a coating for a stent, comprising:
- (a) forming a first coating or layer including an agent on the stent;
- (b) forming a second coating or layer including a polymer over the first coating or layer, the polymer of the second coating or layer having a solubility parameter not greater than approximately 11.5 (cal/cm3)1/2, wherein the second coating reduces the rate of release of the agent.
Dependencies are inferred from the claim text.