Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to release CO and pharmaceutical compositions thereof
AssigneeALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda.
InventorsWerner Haas, Carlos Romao, Beatriz Roya, Ana Cristina Fernandes, Isabel Goncalves
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Abstract
Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g., rheumatoid arthritis, and of diseases with a strong inflammatory component, such as atherosclerosis, stroke, coronary disease, and Alzheimers disease. The in vivo carbon monoxide-releasing compounds can be attached to known drug vectors and/or known anti-inflammatory drugs, such as aspirin.
Claims14
A method for treating a disease in a mammal selected from the group consisting of an inflammatory disease, a disease with a strong inflammatory component, asthma, injury, infarction, and a circulatory disease, wherein said method comprises the step of delivering to said mammal a safe and effective amount of a compound having the ability to release CO in vivo by spontaneous or metabolic process, wherein said compound is a CO containing organometallic complex in a cyclodextrin host that encapsulates at least a portion of the complex or an aggregate of a CO containing organometallic complex and liposome.
A method for generating CO in vivo in a mammal, wherein said method comprises administering to said mammal a safe and effective amount of a compound comprising a supramolecule aggregate comprised of cyclodextrin and a CO-containing organometallic complex of the formula (C6H6−xRx)M(CO)3, where (M=Cr, Mo, W);
- (CpR5)M(CO)3X, where (M=Cr, Mo, W);
- (CpR5)M(CO)2X, where (M=Fe, Ru);
- or (CpR5)M(CO)2, where (M=Co, Rh);
- where
- CpR5 represents indenyl,
- R represents H, alkyl, methoxide, halide or a carboxylic ester,
- subscript x is a positive integer equal to 6 or less,
- X is alkyl, aryl, halide, OR′, SR′, O2CR′, S2CNR′2, or S2P(OR′)2, and
- R′ is alkyl or aryl.
Dependencies are inferred from the claim text.