Method for effecting computer implemented decision-support in the selection of the drug therapy of patients having a viral disease
AssigneeF. Hoffman-LaRoche AG
InventorCharles Achim Bernard Boucher
Life of this patent
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Abstract
A method is described for effecting computer-implemented decision-support in the selection of a drug therapy of patients having a viral disease. A rules database is provided and patient data is entered including genotype data on the viral genome of the viral disease. The rules database comprises a number of associated rules for each available drug for treatment of the viral disease. Each rule indicates the suitability of the drug for treatment of a specific viral genotype. The patient data is entered into the rules database, the database providing an output of drugs suitable for therapy. The drugs suitable for therapy are displayed in a ranking in accordance with their suitability indication, for selection.
Claims43
Method for effecting computer implemented decision-support in selection of a drug therapy of patients having HIV, comprising using a rules database, providing an input of patient data including genotype data on the viral genome of the HIV, wherein the rules database comprises a number of associated rules for each available drug for treatment of the HIV, each rule indicating the suitability of the drug for treatment of a specific HIV viral genotype, entering the patient data into the rules database, the database providing an output of drugs suitable for therapy, and displaying the drugs suitable for therapy in a ranking in accordance with their suitability indication, for selection, wherein the suitability indication of the rules is based on at least a combination of a first value indicating the resistance level of the genotype for the drug and a second value indicating the confidence in the first value.
Method for effecting computer implemented decision-support in selection of a drug therapy of patients having HIV, comprising providing a rules database, providing an input of patient data including genotype data on the viral genome of the HIV, wherein the rules database comprises a number of associated rules for each available drug for treatment of the HIV, each rule indicating the suitability of the drug for treatment of a specific HIV viral genotype, entering the patient data into the rules database, the database providing an output of drugs suitable for therapy, and displaying the individual drugs suitable for therapy in a ranking in accordance with their suitability indication, for selection, wherein the database further comprises a rule for at least one certain drug available for treatment, the rule indicating the suitability of the certain drug for treatment of a specific HIV viral genotype when the drug is taken in combination with another drug, wherein only combinations of drugs are displayed in the ranking with the individual drugs according to the suitability indication for the combination where drugs in the combination influence each other's suitability indication.
Method for effecting computer implemented decision-support in selection of a drug therapy of patients having HIV, comprising providing a rules database, providing an input of patient data including genotype data on the viral genome of the HIV, wherein the rules database comprises a number of associated rules for each available drug for treatment of the HIV, each rule indicating the suitability of the drug for treatment of a specific HIV viral genotype, entering the patient data into the rules database, the database providing an output of drugs suitable for therapy, and displaying the drugs suitable for therapy in a ranking in accordance with their suitability indication, for selection, wherein the suitability indication of the rules is based on at least a first value indicating the resistance level of the genotype for the drug when present at a certain drug level in a patient.
Method for effecting computer implemented decision-support in selection of a drug therapy of patients having HIV, comprising providing a rules database, providing an input of patient data including genotype data on the viral genome of the HIV, wherein the rules database comprises a number of associated rules for each available drug for treatment of the HIV, each rule indicating the suitability of the drug for treatment of a specific HIV viral genotype, entering the patient data into the rules database, the database providing an output of drugs suitable for therapy, and displaying the drugs suitable for therapy in a ranking in accordance with their suitability indication, for selection, wherein the clade is used in the step of selecting a suitable drug therapy.
Dependencies are inferred from the claim text.