Measurement site dependent data preprocessing method for robust calibration and prediction

An apparatus for noninvasively measuring a target analyte in a body using spectroscopic analysis, comprising:

• means for transmitting a probe signal into said body;
• means for detecting said signal responded from said body;
• and
• means for converting said detected signal into a sample measurement of said analyte;
• wherein said means for converting is operable to:
• transform said sample measurement by applying a tissue basis set thereto, said tissue basis set including at least one interfering component, wherein any interference in said sample measurement corresponding to said at least one interfering component in said tissue basis set is removed;
• apply a calibration model to said transformed sample measurement, wherein said calibration model is determined from a calibration set of exemplary paired data points;
• and
• display a noninvasive measurement of said target analyte.

A computer usable medium containing instructions in computer readable form for carrying out a method for noninvasively measuring a target analyte in a body using spectroscopic analysis, said method comprising the steps of:

• collecting a sample measurement which is a response signal from said body to which a probing signal is applied;
• transforming said sample measurement by applying a tissue basis set to said sample measurement, said tissue basis set including at least one interfering component, wherein any interference in said sample measurement corresponding to said at least one interfering component in said tissue basis set is removed;
• calibrating said transformed sample measurement by applying a calibration model, wherein said calibration model is determined from a calibration set of exemplary paired data points;
• and
• determining a noninvasive measurement of said target analyte.

A method for noninvasively measuring a target analyte in a body using spectroscopic analysis, comprising the steps of:

• collecting a sample measurement which is a response signal from said body to which a probing signal is applied;
• transforming said sample measurement by applying a basis set to said sample measurement, said basis set including at least one interfering component, wherein at least one interference in said sample measurement corresponding to said at least one interfering component in said basis set is removed;
• calibrating said transformed sample measurement by applying a calibration model,
• making a bias adjustment on said calibrated measurement, said bias adjustment being associated with each applied basis set and is determined by comparing an analyte measurement with a reference analyte value;
• and
• determining a noninvasive measurement of said target analyte.

A method for noninvasively measuring a target analyte in a body using spectroscopic analysis, comprising the steps of:

• collecting a sample measurement which is a response signal from said body to which a probing signal is applied;
• transforming said sample measurement by applying a basis set to said sample measurement said basis set including at least one interfering component, wherein any interference in said sample measurement corresponding to said at least one interfering component in said basis set is removed, wherein said basis set is determined for each patient and instrument by preprocessing each sample measurement, and then calculating a mathematical representation of the preprocessed sample measurements associated with said each patient and instrument;
• calibrating said transformed sample measurement by applying a calibration model;
• and
• determining a noninvasive measurement of said target analyte.

An apparatus for noninvasively measuring a target analyte in a body using a spectroscopic analysis, comprising:

• means for transmitting a probe signal into said body;
• means for detecting said signal responded from said body;
• and
• means for converting said detected signal into a sample measurement of said analyte;
• wherein said means for converting is operative to:
• transform said sample measurement by applying a basis set thereto, said basis set including at least one interfering component, wherein said basis set is determined for each patient and instrument by preprocessing each sample measurement and then calculating a mathematical representation of the preprocessed sample measurements associated with said each patient and instrument, wherein at least one interference in said sample measurement corresponding to said at least one interfering component in said basis set is removed;
• apply a calibration model to said transformed sample measurement;
• and
• display a noninvasive measurement of said target analyte.

An apparatus for noninvasively measuring a target analyte in a body using spectroscopic analysis, comprising;

• means for transmitting a probe signal into said body;
• means for detecting said signal responded from said body;
• means for converting said detected signal into a sample measurement of said analyte;
• wherein said means for converting is operative to:
• transform said sample measurement by applying a basis set thereto, said basis set including at least one interfering component, wherein any interference in said sample measurement corresponding to said at least one interfering component in said basis set is removed;
• apply a calibration model to said transformed sample measurement;
• and
• make a bias adjustment on said calibration model, said bias adjustment being associated with each applied basis set and is determined by comparing an analyte measurement with a reference analyte value;
• and
• display a noninvasive measurement of said target analyte.