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US 7,009,073 B2Granted
Method for preparing indan-1,3-dicarboxylic acid
AssigneePfizer Inc.
InventorsTimothy J. N. Watson, Mark Christopher Guzman, Patrice Arpin
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Abstract
A method for preparing indan-1,3-dicarboxylic acid compounds which are useful intermediates in the syntheses of aryl fused azapolycyclic compounds as agents for the treatment of neurological and psychological disorders.
Claims10
A process for the preparation of compounds having the formula
- wherein R1 and R2 are selected independently from hydrogen, C1–C5 alkyl, C1–C5 alkoxy, trifluoromethyl, halogen, sulfonyl alkyl, alkylamino, amide, ester, aryl-alkyl, heteroalkyl, and arylalkoxy
- comprising hydrolyzing a compound of formula
- in the presence of an acid or base catalyst
- wherein R1 and R2 are selected independently from hydrogen, C1–C5 alkyl, C1–C5 alkoxy, trifluoromethyl, halogen, sulfonyl alkyl, alkylamino, amide, ester, aryl-alkyl, heteroalkyl, and arylalkoxy.
1 more element
Dependencies are inferred from the claim text.