Process for the production of oxandrolone
AssigneeBarr Laboratories, Inc.
InventorsShaileshkumar Ramanlal Desai, David Wayne Ray, Jr., Yousry A. Sayed
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Abstract
The present invention relates to a process for the synthesis of oxandrolone from mestanolone. The process comprises the steps of: (a) oxidizing mestanolone to form 17β-hydroxy-17α-methyl-5α-androst-1-en-3-one; (b) hydroxylating the 17β-hydroxy-17α-methyl-5α-androst-1-en-3-one to form 1α, 2α, 17β-trihydroxy-17α-methylandrostan-3-one; (c) cleaving the 1α, 2α, 17β-trihydroxy-17α-methylandrostan-3-one to form 17β-hydroxy-17α-methyl-1-oxo-1,2,-seco-A-nor-5α-androstan-2-oic acid; and (d) reducing the 17β-hydroxy-17α-methyl-1-oxo-1,2,-seco-A-nor-5α-androstan-2-oic acid to form oxandrolone.
Claims11
A process for the production of 17β-hydroxy-17α-methyl-5α-androst-1-en-3-one, the process comprising reacting mestanolone with IBX to form 17β-hydroxy-17α-methyl-5α-androst-1-en-3-one.
Dependencies are inferred from the claim text.