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US 7,009,055 B2Granted
Preparation of Sulfonyl quinoline
AssigneeMerck & Co., Inc.
InventorsFeng Xu, Kimberly A. Savary, John M. Williams
Life of this patent
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Abstract
A dibromomethyl moiety is converted to a sulfonylmethyl moiety by treatment with a sulfinic acid salt. For example, (methyl-sulfonyl)methyl bromo-quinoline is prepared by the treatment of dibromomethyl bromo-quinoline with a sulfinic acid salt.
Claims5
A method of forming a reaction product mixture substantially containing
- wherein X is an aryl or heteroaryl, and R is a C1-6 alkyl or aryl, said method comprising:
- reacting
- in an effective amount of a sulfinic acid salt (RSO2 salt) in an effective amount of solvent.
A method of forming a reaction product mixture substantially containing:
- said method comprising:
- reacting
- in an effective amount of a sulfinic acid salt in an effective amount of solvent at an effective temperature.
Dependencies are inferred from the claim text.