Sulfonamide derivatives

A compound of the formula:

• or a pharmaceutically acceptable salt or solvate thereof, in which:
• a. M is NZ or O;
• b. Z is represented by H or (C1–C4)alkyl;
• c. R1 is represented by (C1–C2)alkyl, optionally substituted with one or more halogens, or (C1–C2)alkoxy, optionally substituted with 1 or more halogens;
• d. R2 is absent, or may represent up to 2 substituents selected from the group consisting of halogen, nitrile, hydroxy, (C1–C4)alkyl, (C2–C4)alkenyl, (C2–C4)alkynyl, (C1–C4)alkoxy, (C1–C2)alkyl substituted with 1 or more halogens, (C1–C2)alkoxy substituted with one or more halogens, SR4, and NR4R5;
• e. R4 is represented by hydrogen, optionally substituted phenyl, (C1–C4)alkyl, or optionally substituted benzyl;
• f. R5 is represented by optionally substituted phenyl, optionally substituted heteroaryl, or optionally substituted heterocyclic
• g. A and B are each independently represented by a substituent selected from the group consisting of hydrogen, (C1–C6)alkyl optionally substituted with one or more halogens, (C2–C6)alkenyl, (C2–C6)alkynyl, optionally substituted (C3–C8) cycloalkyl, optionally substituted (C5–C8) cycloalkenyl, optionally substituted phenyl, optionally substituted cycloalkylphenyl, optionally substituted heterocyclic, optionally substituted heteroaryl, (C1–C6)alkylR6, —(CH2)m—R7—Y[—CH2]n—X—R8, and —(CH2)qCHX1X2;
• h. R6 is represented by a substituent selected from the group consisting of nitrile, OH, optionally substituted phenyl, optionally substituted cyloalkylphenyl, optionally substituted heterocyclic, optionally substituted heteroaryl, optionally substituted (C3–C8) cycloalkyl, optionally substituted (C5–C8) cycloalkenyl, SR4, and NR4R5;
• i. R7 is absent, or is represented by a substituent selected from the group consisting of optionally substituted (C3–C8) cycloalkyl, optionally substituted (C5–C8) cycloalkenyl, optionally substituted heteroaryl, optionally substituted heterocyclic, and optionally substituted phenyl;
• j. R8 is absent, or is represented by a substituent selected from the group consisting of (C1–C6)alkyl optionally substituted with one, or more, halogens, optionally substituted (C3–C8) cycloalkyl, optionally substituted (C5–C8) cycloalkenyl, optionally substituted heteroaryl, optionally substituted heterocyclic, optionally substituted phenyl, and optionally substituted cycloalkylphenyl;
• k. m is an integer selected from 0, 1, 2, 3, or 4;
• l. Y is absent, or is represented by O, C(O), C(O)O, CH2C(O)O, OH, SH, or S;
• m. n is represented by an integer selected from 0, 1, 2, 3, or 4;
• n. X is absent, or is represented by O, C(O), C(O)O, CH2C(O)O, OH, SH, or S;
• o. q is represented by an integer selected from 0, 1, 2, 3, or 4;
• p. X1 is represented by a substituent selected from the group consisting of optionally substituted (C3–C8) cycloalkyl, optionally substituted (C5–C8) cycloalkenyl, optionally substituted heteroaryl, optionally substituted heterocyclic, optionally substituted phenyl, and optionally substituted cycloalkylphenyl, and;
• q. X2 is represented by a substituent selected from the group consisting of optionally substituted (C3–C8) cycloalkyl, optionally substituted (C5–C8) cycloalkenyl, optionally substituted heteroaryl, optionally substituted heterocyclic, optionally substituted phenyl, and optionally substituted cycloalkylphenyl.