HCV/BVDV chimeric genomes and uses thereof
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsJae-Hwan Nam, Jens Bukh, Suzanne U. Emerson, Robert H. Purcell
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Abstract
The present invention relates to molecular approaches to the production of nucleic acid sequences which comprise the genomes of chimeric hepatitis C virus-bovine viral diarrhea viruses (HCV/BVDV). The invention also relates to the use of these chimeric nucleic acid sequences to produce chimeric virions in cells and the use of these chimeric virions in HCV antibody neutralization assays, and for the development of vaccines and therapeutics for HCV.
Claims15
A nucleic acid molecule comprising a chimeric virus genome, said genome being a bovine viral diarrhea virus (BVDV) genome in which at least one gene from the structural region of the BVDV genome has been replaced by the corresponding gene from the structural region of a hepatitis C virus genome.
Dependencies are inferred from the claim text.