Plus end-directed microtubule motor required for chromosome congression
AssigneeThe Regents of the University of California
InventorsKenneth W. Wood, Roman Sakowicz, Lawrence S. B. Goldstein, Don W. Cleveland
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Abstract
The invention provides isolated nucleic acid and amino acid sequences of Xenopus CENP-E (XCENP-E), antibodies to XCENP-E, methods of screening for CENP-E modulators using biologically active CENP-E, and kits for screening for CENP-E modulators.
Claims13
An isolated nucleic acid sequence encoding a protein comprising an amino acid sequence that has greater than 80% amino acid sequence identity to amino acid residues 1-324 of SEQ ID NO:1, wherein said protein has at least one activity chosen from (a) plus end-directed microtubule motor activity, (b) ATPase activity, and (c) microtubule binding activity.
An isolated nucleic acid sequence encoding a protein comprising amino acid residues 1-324 of SEQ ID NO:1.
Dependencies are inferred from the claim text.