Plasma protein matrices and methods for their preparation
AssigneeProChon Biotech Ltd.
InventorsAvner Yayon, Rachel Glicklis
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Abstract
A freeze dried biocompatible matrix comprising plasma proteins, useful as implants for tissue engineering as well as in biotechnology, and methods of producing the matrix are provided. Mechanical and physical parameters can be controlled by use of auxiliary components or additives which may be removed after the matrix is formed in order to improve the biological properties of the matrix. The matrices according to the present invention may be used clinically per se, or as a cell-bearing implant.
Claims53
An elastic freeze-dried biocompatible porous fibrin matrix useful as a scaffold for growing cells, wherein the matrix has substantially regular pores and a residual moisture below 3% and is obtained by mixing lplasma proteins comprising fibrinogen and Factor XIII with thrombin and at least one anti-fibrinolytic agent in substontial absence of organic chelating agents.
Dependencies are inferred from the claim text.