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US 7,009,036 B2Granted
Peptide inhibiting platelet derived growth factor (PDGF-BB) and fibroblast growth factor (bFGF) activity
AssigneeProvincia Italiana Della Congregazione Dei Figli Dell'Immacolata Concezione—Instituto Dermopatico Dell'Immacolata
InventorsAntonio Facchiano, Francesco Facchiano, Angelo Facchiano
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Abstract
A novel peptide, derived from the human fibroblast growth factor (bFGF), is identified. The molecule is able to inhibit in vitro the effects of Platelet Derived Growth Factor (PDGF-BB) and basic Fibroblast Growth Factor (bFGF) on primary rat smooth muscle cells (RASMC) and primary bovine endothelial cells (BAEC) The molecule is also able to inhibit in vivo angiogenesis CD1 mice.
Claims1
An isolated peptide consisting of Asp-Pro-His-Ile-Lys-Leu-Gln-Leu-Gln-Ala-Glu (SEQ ID NO:
- 1).
Dependencies are inferred from the claim text.