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US 7,008,962 B2Granted
IL-8 receptor antagonists
AssigneeSmithKline Beecham Corporation
InventorsMichael R. Palovich, Brent McCleland, Guangping Bi, Michelle Werner, Katherine L. Widdowson
Life of this patent
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Abstract
This invention relates to the novel use of dianilino squarates in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
Claims4
The compound selected from the group consisting of:
- 3-(2-hydroxy-phenylamino)-4-(2-bromophenylamino)-cyclobut-3-ene-1,2-dione,
- 3-(2-hydroxy-phenylamino)-4-(2,3-dichlorophenylamino)-cyclobut-3-ene-1,2-dione,
- 3-(4-nitro-2-hydroxy-phenylamino)-4-phenylamino-cyclobut-3-ene-1,2-dione,
- 3-(4-cyano-2-hydroxy-phenylamino)-4-phenylamino-cyclobut-3-ene-1,2-dione,
- 3-(2-methoxy-benzylamino)-4-phenylamino-cyclobut-3-ene-1,2-dione,
- 3-(4-cyano-2-hydroxy-phenylamino)-4-(2-bromophenylamino)-cyclobut-3-ene-1,2-dione,
- 3-(4-cyano-2-hydroxy-phenylamino)-4-(2-chlorophenylamino)-cyclobut-3-ene-1,2-dione,
- 3-(4-cyano-2-hydroxy-phenylamino)-4-(2,3-dichlorophenylamino)-cyclobut-3-ene-1,2-dione,
- 3-(2-Hydroxy-phenylamino)-4-(2-phenylphenylamino)-cyclobut-3-ene-1,2-dione,
- 3-(2-Hydroxy-phenylamino)-4-(2-methoxyphenylamino)-cyclobut-3-ene-1,2-dione,
- 3-(2-Hydroxy-phenylamino)-4-(2-ethylphenylamino)-cyclobut-3-ene-1,2-dione,
- 3-(2-Hydroxy-phenylamino)-4-(2-phenoxyphenylamino)-cyclobut-3-ene-1,2-dione,
- 3-(2-Hydroxy-phenylamino)-4-(2-chlorophenylamino)-cyclobut-3-ene-1,2-dione,
- 6-Chloro-3-(3,4-dioxo-2-phenylamino-cyclobut-1-enylamino)-2-hydroxy-benzenesulfonamide,
- 3,4-bis-(4-cyano-2-hydroxyphenylamino)-cyclobut-3-ene-1,2-dione,
- 3-(2-Hydroxy-phenylamino)-4-(2,3-dimethylphenylamino)-cyclobut-3-ene-1,2-dione,
- 3-(2-Hydroxy-phenylamino)-4-(2-methyl-4-bromophenylamino)-cyclobut-3-ene-1,2-dione,
- 3-(2-Hydroxy-phenylamino)-4-(2-propylphenylamino)-cyclobut-3-ene-1,2-dione,
- 3-(2-Hydroxy-phenylamino)-4-(2-methyl-3-chlorophenylamino)-cyclobut-3-ene-1,2-dione,
- 3-(2-Hydroxy-phenylamino)-4-(2,3-dimethoxyphenylamino)-cyclobut-3-ene-1,2-dione,
- 3-(2-Hydroxy-phenylamino)-4-(2-chloro-3-methylphenylamino)-cyclobut-3-ene-1,2-dione,
- 3-(4-nitro-2-hydroxy-phenylamino)-4-(2-bromophenylamino)-cyclobut-3-ene-1,2-dione,
- 3-(4-nitro-2-hydroxy-phenylamino)-4-(2-chlorophenylamino)-cyclobut-3-ene-1,2-dione,
- 3,4-bis-(4-nitro-2-hydroxyphenylamino)-cyclobut-3-ene-1,2-dione,
- 3-[(2-Hydroxy-phenyl)-methyl-amino]-4-phenylamino-cyclobut-3-ene-1,2-dione,
- 3-(3-Hydroxy-pyridin-2-ylamino)-4-phenylamino-cyclobut-3-ene-1,2-dione, and
- or a pharmaceutically acceptable salt thereof.
24 more elements
Dependencies are inferred from the claim text.