US 7,008,955 B2 · (2-azabicyclo[2.2.1]hept-7yl) methanol derivatives as nicotinic acetylcholine receptor agonists

Abstract

The present invention relates to substances of the general formula (I) in which X is selected from the group consisting of NH, NR4, O and S, R1 is selected from the group consisting of hydrogen, linear and branched, substituted and unsubstituted C1–C10-alkyl groups, substituted and unsubstituted C5–C10-aryl groups, substituted and unsubstituted C4–C10-heteroaryl groups, acyl groups, thioacyl groups, carbonylcarboxy groups, N-organyl-substituted carbamoyl groups and organosulfonyl groups, R2, R3 are selected, independently of one another, from the group consisting of C1–C10-alkyl groups, C5–C12-aryl groups and C4–C12-heteroaryl groups, these groups being unsubstituted or having one or more substituents which are selected, independently of one another, from the group consisting of halogens, alkoxy groups, aryloxy groups, nitro groups, C1–C5-alkoxycarbonyl groups, optionally fluorine-substituted alkyl or acyl groups and cyano groups, R4 is selected from the group consisting of hydrogen, linear and branched, substituted and unsubstituted C1–C10-alkyl groups, substituted and unsubstituted C5–C10-aryl groups, substituted and unsubstituted C4–C10-heteroaryl groups, aryl groups, thioacryl group, carbonylcarboxy groups, N-organyl-substituted carbamoyl groups and organosulfonyl groups, or a physiologically acceptable salt thereof.

Claims6

Dependent claims

A compound of formula

in which
the broken line represents a double bond which is optionally present,
X is NH, NR4, O or S,
R1 is hydrogen, a linear or branched, substituted or unsubstituted C1–C10-alkyl group, substituted or unsubstituted C5–C10-aryl group, substituted or unsubstituted C4–C10-heteroaryl group, acyl group, thioacyl group, carbonylcarboxy group, N-organyl-substituted carbamoyl group or organosulfonyl group,
R2, R3
and R4 are, independently of one another, a C1–C10-alkyl group, C5–C12-aryl group or C4–C12-heteroaryl group, these groups being unsubstituted or having one or more substituents which are, independently of one another, a halogen, alkoxy group, aryloxy group, nitro group, C1–C5-alkoxycarbonyl group, optionally fluorine-substituted alkyl or acyl group or cyano group,
or a physiologically acceptable salt thereof.

4 more elements

Dependencies are inferred from the claim text.

(2-azabicyclo[2.2.1]hept-7yl) methanol derivatives as nicotinic acetylcholine receptor agonists

Life of this patent

(2-azabicyclo[2.2.1]hept-7yl) methanol derivatives as nicotinic acetylcholine receptor agonists

Life of this patent

Abstract

Claims6