Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-Dioxino[2,3-f]quinoxaline

A method of treating a subject suffering from a condition selected from the group consisting of obesity, anorexia nervosa, bulimia nervosa, vasomotor flushing, alcohol addiction, and premature ejaculation, which comprises providing to the subject suffering from said condition, a therapeutically effective amount of a compound of formula I

• wherein
• R1, R4, R5, R6 and R8 are, independently, hydrogen, hydroxy, halo, cyano, carboxamido, carboalkoxy of two to six carbon atoms, trifluoromethyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkanoyloxy of 2 to 6 carbon atoms, amino mono- or di-alkylamino in which each alkyl group has 1 to 6 carbon atoms alkanamido of 2 to 6 carbon atoms, or alkanesulfonamido of 1 to 6 carbon atoms;
• R2 and R3 are, independently, hydrogen, alkyl of 1 to 6 carbon atoms, halogen, hydroxy, cyano or amino;
• R7 is hydrogen or alkyl of 1 to 6 carbon atoms;
• the dotted line represents an optional double bond;
• Z is CR8 or N;
• and
• n is an integer 0, 1 or 2;
• or a pharmaceutically acceptable salt thereof.