1-(Pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives

A compound of the Formula (I):

• wherein:
• R3, R5 and R6 are independently selected from the group consisting of hydrogen, alkyl, trihaloalkyl, cycloalkyl, alkenyl, alkynyl, aryl, hydroxy, alkoxy, aryloxy, mercapto, alkylthio, arylthio, sulfinyl, sulfonyl, S-sulfonamido, N-sulfonamido, trihalomethane-sulfonamido, carbonyl, C-carboxy, O-carboxy, C-amido, N-amido, cyano, nitro, halo, O-carbamyl, N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, amino and —NR11R12, where R11 and R12 are independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, carbonyl, acetyl, sulfonyl, trifluoromethanesulfonyl and, together with the nitrogen to which they are attached, form a five- or six-member heteroalicyclic ring;
• R7 is hydrogen;
• R4 is halo;
• R8 and R10 are independently unsubstituted lower alkyl;
• and
• R9 is lower alkyl substituted with C-carboxy, or —C(═O)NHR13 wherein R13 is lower alkyl substituted with amino or heteroalicyclic and optionally substituted with hydroxyl.