Dihydrobenzofuran derivatives, process for the preparing thereof and agents
AssigneeTakeda Pharmaceutical Company Limited
InventorsShigenori Ohkawa, Tadatoshi Hashimoto, Tetsuya Tsukamoto
Life of this patent
Estimating the term…
Abstract
A compound represented by the formula (I): or a salt thereof exhibits excellent inhibitory activity of lipid peroxidation and is useful as an agent for inhibiting lipoperoxide production, wherein ring A denotes a non-aromatic 5- to 7-membered nitrogen-containing heterocyclic ring which may be further substituted, B ring denotes a benzene ring which may be further substituted, C ring denotes a dihydrofuran ring which may be further substituted, and R denotes hydrogen atom or an acyl group.
Claims20
A compound represented by the formula:
- wherein A ring denotes a non-aromatic 5-membered nitrogen-containing heterocyclic ring of at least one nitrogen atom and carbon atoms and may have a further substituent selected from the group consisting of:
- an optionally substituted hydrocarbon group,
- an optionally halogenated lower alkoxy group,
- an optionally halogenated lower alkylthio group,
- a halogen atom,
- an aryloxy group,
- a lower alkanoyl group,
- an arylcarbonyl group,
- a lower alkanoyloxy group,
- an arylcarbonyloxy group,
- a carboxyl group,
- a lower alkoxy-carbonyl group,
- a carbamoyl group,
- a thiocarbamoyl group,
- a mono-lower alkylcarbamoyl group,
- a di-lower alkylcarbamoyl group,
- a C6-10 aryl-carbamoyl group,
- an amidino group,
- an imino group,
- an amino group,
- a mono-lower alkylamino group,
- a di-lower alkylamino group,
- a 3- to 6-membered cyclic amino group optionally containing 1 to 3 heteroatoms selected from the group consisting of oxygen atom, sulfur atom and nitrogen atom, in addition to carbon atoms and one nitrogen atom, an alkylenedioxy group,
- a hydroxy group,
- a nitro group,
- a cyano group,
- a mercapto group,
- a sulfo group,
- a sulfino group,
- a phosphono group,
- a sulfamoyl group,
- a mono-lower alkylsulfamoyl group,
- a di-lower alkylsulfamoyl group,
- an arylthio group,
- a lower alkylsulfinyl group,
- an arylsulfinyl group,
- a lower alkylsulfonyl group, and
- an aryl sulfonyl group;
- B ring denotes a benzene ring which may be further substituted;
- C ring denotes a dihydrofuran ring which may be further substituted;
- and
- R denotes hydrogen atom or an acyl group;
- or a salt thereof.
A method for treating restenosis after percutaneous transluminal coronary angioplasty which comprises administering a compound represented by the formula:
- wherein Aa ring denotes a non-aromatic 5-membered nitrogen-containing heretocyclic ring which may be further substituted, Ba ring denotes a benzene ring which may be further substituted, Ca ring denotes a dihydrofuran ring which may be further substituted, and Ra denotes hydrogen atom or an acyl group, or a salt thereof, to a mammal.
A method for treating Alzheimer's disease which comprises administering a compound represented by the formula:
- wherein Aa ring denotes a non-aromatic 5-membered nitrogen-containing heretocyclic ring which may be further substituted, Ba ring denotes a benzene ring which may be further substituted, Ca ring denotes a dihydrofuran ring which may be further substituted, and Ra denotes hydrogen atom or an acyl group, or a salt thereof, to a mammal.
Dependencies are inferred from the claim text.